In this part we do not mofaremos of aspirin, well, a little, but not quite ...
By: NEMATTZZI JAIGUERY SPINNIN
ASPIRIN ...
trade name Aspirin comes from the word "Pirates", which designates a family of botanical plants and hence the syllable "Sir." The letter "A" indicates the process of acetylation which is submitted to the salicylic acid into acetylsalicylic acid. The syllable "in" was a frequently used ending for drugs at the time.
headache, menstrual pain, muscle pain ... are types of pain that occur in our daily lives but what is it and how does the pain?
to relieve, Felix Hoffman summed up, in 1897, acetylsalicylic acid, an active principle whose first and best known indications show it as an analgesic, antipyretic and anti-inflammatory, effective and well tolerated.
DISCOVER ... Throughout its 100 year history, Aspirin has emerged as a drug highly indicated in several cases.
addition to its classical indications (anti-inflammatory, antipyretic DISMUNUCION OF FOOT "" and analgesic), the various investigations carried out in recent years have found new and interesting directions for the treatment of other diseases (cardiovascular, cerebrovascular, etc.). ...
THE HISTORY OF ASPIRIN
In ancient times, the remedy is found in nature. In particular, the extract from the bark of white willow (Salix alba), whose active ingredient is the substantial base of aspirin, had a soothing therapeutic qualities such as fever and relieve pain. Over time, natural remedies paved the way for scientific research and chemical solutions.
Further investigations and modifications of willow bark were active in this plant that scientists called salicin, used to synthesize salicylic acid, and acetylation process leads to aspirin.
Forty-four years later the first attempt of acetylation of salicylic acid, Felix Hoffmann, a young chemist at the Bayer Company, managed to obtain pure and stable form acetylsalicylic acid marketed under the name after Aspirin. From then until now, Aspirin has been sold around the world ... ...
ACID SALISILICO
To prevent a possible shortage of salicin in the near future, creating the need to find the chemical formula to synthesize this substance from willow bark. In 1859, Herman Kolbe received salicylic acid, synthesis of salicin. This compound has some disadvantages, such as its excessive bitterness and irritation in the stomach that caused ingestion.
acetyl
SALSILICO ... In 1853, French chemist Charles Frederic Gerhardt made a first attempt to acetylation de la salicina pero la solución contenía demasiados efectos secundarios e impurezas. Aún así, sus experimentos fueron recogidos en la literatura científica del momento, aunque a la vez olvidados por la comunidad médica. Cuarenta y cuatro años más tarde, Félix Hoffmann recuperó del pasado estas investigaciones y las perfeccionó, obteniendo el ácido acetilsalicílico, principio activo de Aspirina.
FELIX HOFFMANN…
Arthur Eichengrün, director del grupo de investigación de nuevos fármacos de la Compañía Bayer en 1896, encargó a Félix Hoffmann la resolución de una variante del ácido salicílico que redujera los efectos secundarios the original. Felix Hoffmann's father suffered from chronic rheumatism treated with salicylic acid. The interest of young chemist ensure the success of the investigation. On October 10, 1897, Felix Hoffmann reported the procedure for obtaining the so-called acetylsalicylic acid. His method of work focused on modifying and improving the experiments in 1853 by Frenchman Charles Frederic Gerhardt. Hoffmann's research led to a more stable and chemically pure, than his predecessor.
...
Bayer Bayer was born as a company dedicated to the dye industry, before becoming a pharmaceutical company. At that time, the supervisor of patents and research department of Bayer, Carl Duisberg, decided to investigate all possible avenues to create a paranitrophenol antipyretic. This decision was taken following the accidental discovery. Some doctors had managed acetanilina Alsatian about sick of parasitic infections, instead of naphthalene. The acetanilina is a product used in the dye industry. Surprisingly they found themselves before an antipyretic unknown so far. The paranitrophenol was a waste product in the manufacture of dyes chemically very similar to the acetanilina, of which there were thousands of kilos stored in the factory without a destination or use. In 1888 he obtained a chemical called Duisberg acetophenetidin that name was not released with a chemical. Phenacetin, the first drug from Bayer.
CURIOSITIES ... Why is aspirin white?
Not all dosage forms of aspirin have a range white. White alone are the following: Aspirin adults, C Effervescent Aspirin and cafiaspirins. White is because the raw materials used in their production are white and they have no process that changes its color. Also, no dyes are used in its preparation.
Why Aspirin is round? Aspirin
began to be marketed in powder form. Technological advances enabled the manufacture of tablets, which made it more convenient dosing and sampling. The rounded shape is what allows a better swallowing their intake.
CONCLUSIONS ... We continue to see and realize that the drug aspirin is a little or much more indispensable in the use of any and all human communities, the simple question is: who in his life has taken an aspirin? ... is very cool ... but I feel there is something behind this ... but ... this time is not critical ... just present this work today research and there ...
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